How to Upload Raw Dna to Promethease
Promethease Review Summary
Summary
Promethease provides detailed wellness reports for a price lower than most competitors. The interface could exist difficult for outset time users.
This review is written with the intent to be as unbiased as possible. However, information technology represents the opinion of an individual reviewer and is therefore subjective. Furthermore, at Nebula Genomics we seek to educate the public about the benefits of Whole Genome Sequencing. Information about our Whole Genome Sequencing Dna test is therefore incorporated into the review.
October 6, 2021
Table of contents
- seven facts from our Promethease Review
- Promethease Introduction
- Overview
- Getting Started with Promethease
- How to Utilize Promethease
- Review of Promethease Privacy
- Promethease in the News
- Promethease Dna Reviews
- Pros and Cons
- Pros
- Cons
- Nebula Genomics
- Nebula Aggrandize
- Whole-Genome Sequencing
Edited by Christina Swords, Ph.D.
7 facts from our Promethease Review
- Location: Promethease was recently caused past MyHeritage which is located in Israel
- Products: DNA data upload for health reporting
- Reports: very detailed on disease risks, but sometimes difficult to understand
- Result commitment: through the Promethease website
- Privacy: data deleted automatically after 45 days
- Cost: $12
- Alternatives: Nebula Genomics (free DNA upload and reporting based on latest scientific discoveries)
Promethease Introduction
Promethease is a website used for genome wellness reporting. The site was launched in 2008 and is based on the SNPedia wiki. Both websites were acquired in 2019 past the genealogy platform MyHeritage. Promethease and SNPedia have become one of the most widely used sites for Deoxyribonucleic acid health reporting.
The company uses the SNPedia's extensive research library to inform users of their genetic variants. The SNPedia library contains health information on over 100,000 gene variants. Each entry in the SNPedia library is selected based on actual genetic information and results from peer-reviewed scientific research. Read more in our Promethease review!
Overview
Allow'southward start the review with an overview of the Promethease service. The company is a Deoxyribonucleic acid data analysis and literature retrieval organisation that does non offer DNA testing services. Instead, this visitor focuses on analyzing genetic markers in uploaded raw Dna information and providing detailed wellness reports. It does not offer any DNA ancestry or family tree maker services.
It is designed to be compatible with raw data from other genetic testing providers. The Promethease test is compatible with raw DNA data exports from Nebula Genomics, 23andMe, AncestryDNA, etc.
Their flagship product is a DNA health written report. This report is based on genetic data from bookish research aggregated on SNPedia.com — a database of single nucleotide polymorphisms (SNPs).
The health study is presented every bit a list of relationships between users' cistron variants and health traits. Each item carries a brief description, details most biology, and an assessment of the medical significance. This service tin can be used to analyze medical history and genetic wellness risks based on family history.
The company is very transparent about the sources of its data. Users can become from their results to the scientific studies behind those results with merely a few clicks.
Each Promethease DNA report costs $12 and is generated in under 15 minutes. Does Promethease offering discounts? Non unremarkably. Nevertheless, you lot can upload multiple DNA raw data files at once for a reduced toll. The first upload costs $12 simply simultaneous additional files only price but $4.
Want the well-nigh comprehensive sequencing to run through Promethease?
Nebula Genomics offers Whole Genome Sequencing, providing 10,000 times more data than well-nigh genotyping based genomics tests. Nebula offers variant interpretation tools, deep ancestry, and new reports every week. This data can also exist run through Promethease for boosted analysis.
Getting Started with Promethease
Before we review Promethease reporting, let's accept a wait at how to get started using the service. Their website starting time greets users with its terms and weather. Users must concord to weather, such as:
"I accept the chance of learning that I may exist at high risk for a debilitating disease"
And "I am aware that I am strongly encouraged to discuss my Promethease report with a doctor"
Later accepting the terms, users are asked to watch a tutorial video from 2016. The video tin be viewed hither:
Getting started takes simply a few minutes, depending on the file size. Simply upload your raw Dna data (e.yard. files from 23andMe, AncestryDNA, VCF, etc.). Then purchase the report, and enter your contact information.
The company generates the report, and you will receive a link to information technology in an email.
How to Use Promethease
In this office of our Promethease review, we will examine the provided reporting. They offer sample reports for customers to review before uploading their data and buying reports. The study results are made available through a web browser. Sections of these tin can likewise exist downloaded to PDFs or exported to Excel spreadsheets.
Upon opening their results, users find a list of gene variants from their uploaded DNA file that Promethease analyzed.
Promethease reports are highly customizable. For example, users can search for specific medical conditions like AIDS or prostate cancer. Users tin can also filter past the number of academic references and the force of the evidence. This is specially useful because many other Deoxyribonucleic acid analysis services provide reports without explaining how they were produced.
Users tin can also search past keywords for specific genes, body parts, or conditions. For instance, you tin can search for variants in the MTHFR gene or BRCA1 gene, the latter of which is closely associated with breast cancer. Yous tin can also search for keywords like eyes or cancer.
Each study issue is assigned a repute that tin can be "good", "bad", or "not set." This indicates whether the user'south Dna has a positive or negative impact on health. For example, whether specific SNPs analyzed decrease or increment the adventure of a medical condition.
The report as well gives each gene variant a score or "magnitude." Magnitudes are subjective measures of how interesting the gene variant is. They indicate how of import it is for the user to pay attention to the result.
For example, the sample report of Alzheimer's shows a 2-times greater adventure of the condition with a magnitude of three.v. That would be a BAD repute, significant that the user has a SNP that increases the risk of developing Alzheimer's. The magnitude of 3.five suggests that the take a chance increase is quite pregnant. Promethease suggests paying attention and maybe reaching out to a medical professional.
Users tin can also filter their Promethease Deoxyribonucleic acid analysis reports information by category. The categories are broken upwards into the three subsets:
- Topics, such as height, gout, and Ashkenazi Jewish
- Medical conditions, such every bit alcoholism, insomnia, and kidney stones
- Clinvar Diseases, such as crevice chin, Tay-Sachs disease, and Familial Mediterranean fever
All reports include gene names and SNP IDs. If users click on them, they are taken to the SNPedia page. Here, users tin review peer-reviewed research to learn more about each cistron, variant, and medical condition.
Because the SNPedia database is and then comprehensive, Promethease suggests going over results with your doc, genetic counselor or another medical professional. In item, if you are concerned well-nigh a particular result.
Review of Promethease Privacy
Their privacy policy was updated after the site was acquired past MyHeritage. All personal data is transferred to and processed in the U.s..
Is Promethease safe? User Deoxyribonucleic acid raw data files are deleted automatically after 45 days. Creating an business relationship is optional. If users practice not create an account, their DNA information files are deleted later 24 hours.
Will Promethease disembalm your personal data to 3rd parties? The site says information technology may share users' information to third parties, such as payment processors, that assistance the company offer its services. It may also transfer user data in the event of another company acquisition, such as happened during the MyHeritage acquisition.
Promethease in the News
An article from 2018 published in the Seattle Times showed how a radiology resident at Baylor University Medical Center in Dallas got a imitation positive. He tested himself on 23andMe but and so submitted his raw data to Promethease and got a alert that he had a mutation linked to Lynch syndrome.
Promethease was a safety and independent computer program developed by SNPedia that promised anonymity and devastation of data within 45 days. Users so realized that information technology was acquired past MyHeritage in 2019.
Promethease DNA Reviews
Amazon user R. Holzle makes a thorough customer review of their feel using 23andMe, AncestryDNA, and Promethease. They updated this review in 2019 after MyHeritage purchased the company. In general, the review is neutral in that the service provides useful insights on the risks of conditions.
User reviews of Promethease on Reddit compare Promethease to Xcode Life.
Pros and Cons
Pros
- Full of detailed health information
- Less expensive than most other health reporting services
- One single detailed health written report generated quickly
- Transparent nearly scientific rigor. Tin can filter out weakly supported results.
Cons
- User interface not easy to understand
- Unregulated access to DNA wellness information can be misconstrued
- Potential for faux positives due to varying degrees of research rigor
Nebula Genomics
We finish our review by comparing Promethease with Nebula Genomics and other DNA testing and assay sites. Nebula Genomics stands out compared to other genomic health reporting services. Nosotros prioritize privacy above all else. We besides offer whole genome sequencing, the most advanced genetic test. It enables us to provide the most comprehensive reporting that is updated every week based on the latest enquiry.
Nebula Expand
Do you accept DNA examination results from other testing sites like Ancestry or 23andMe? You can upload that data to Nebula for free. We will expand your Deoxyribonucleic acid data and give you access to a detailed written report.
How practice nosotros accomplish detailed reporting on genetic conditions? Our expanded reports are generated statistical models to make full in the blanks left behind by typical Dna genotyping tests. A genetic testing visitor similar Promethease can provide information on some variants, merely our expanded reports tin clarify most all variants.
We alive in a time of a genomic revolution that is changing our lives. We empower our users to stay informed about cutting-edge enquiry and learn how it affects them. We curate the latest research, personalize information technology based on your genomic information, and provide detailed reports through the Nebula Research Library.
Whole-Genome Sequencing
We also go beyond DNA data uploads. With our 30x Whole-Genome Sequencing service, we tin determine 100% of your Deoxyribonucleic acid. With u.s., you become 10,000 times more data than with other services that, in contrast, only read 0.one% of your genome!
Hither is how Nebula compares with other DNA testing companies.
| | 23andMe | Beginnings | Promethease | Nebula Genomics |
| Type of Genome Reporting Service | Microarray-based genotyping & written report | Microarray-based genotyping & report | Wellness-oriented genome analysis | Whole-Genome Sequencing (30x coverage) |
| Produced data | ~ 600,000 positions in the genome | ~ 700,000 positions in the genome | North/A | ~ 3,000,000,000 positions in the genome |
| Compatible with other sites | Tin can consign data and utilise information technology elsewhere | Tin can consign data and use it elsewhere | Accepts all typical Dna testing data (e.g. 23andMe, AncestryDNA and Nebula Genomics raw data) | Tin can export information and employ elsewhere or upload data from 23andMe/AncestryDNA to make full in gaps and acquire more |
| Affiliated Companies | Yes | Aye | Owned past MyHeritage | Deep beginnings reporting with full Y chromosome and mtDNA sequencing in collaboration with FTDNA |
| Target Customer | Consumers who are interested in a express at-habitation genetic test | Consumers who are interested in a limited at-home genetic test | Consumers who are interested in detailed health reports with references | Consumers who are interested in complete DNA testing and advanced reporting |
| User interface | Highly rated | Highly Rated | Less easy to sympathize than competitors | Highly Rated |
| Privacy Prioritized | No | No | No | Yep (acquire more) |
| Cost | $99 or $199 | $99 or $119 | $12+ | $0, $99, $299 |
Promethease vs Ancestry vs 23andMe vs Nebula Genomics
Other alternatives to Promethease you should consider are:
- 24Genetics (health tests)
- Genetic Genie, (gratis; for health information)
- GeneSight (pharmacogenomics Dna testing)
- Genomelink (25 traits reported for free)
- HealthCodes Dna (personalized plans for wellness, diet, and fitness)
- myDNA (personalized fitness, diet, and medication plans)
- Xcode Life (fitness and health report)
One time yous understand your detailed health study, many great supplement companies out there may assistance y'all lose weight and get healthy (you can read about many of them on our weblog!) But be careful! There are likewise dangerous experimental drugs out there like SR9009 and RAD 140 that are not approved for human consumption.
Did you like our Promethease review? You tin can read more reviews on our weblog and check out our consummate guide to the best DNA exam kit and other dwelling tests.
Source: https://nebula.org/blog/promethease-review/
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